21c Museum Hotel Lexington

21c Museum Hotel Lexington combines a boutique hotel, contemporary art museum, and acclaimed restaurant in a beautifully restored building on West Main Street. The museum galleries and private event spaces double as art-filled environments where rotating exhibitions provide a constantly fresh visual backdrop for celebrations.

Private events can be hosted in dedicated gallery rooms, the mezzanine lounge, or the restaurant’s private dining area. The hotel’s culinary team, led by the on-site restaurant Lockbox, delivers inventive Southern cuisine with a refined touch. For corporate events, the combination of art, food, and lodging under one roof simplifies planning considerably. The downtown location keeps guests connected to Lexington’s walkable entertainment district, and the contemporary art programming gives every event at 21c a cultural dimension that conventional venues cannot match.